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NUB1 rabbit pAb

一鍵復(fù)制產(chǎn)品信息

ES2990

規(guī)格：	價(jià)格：
50μL	￥1280.00
100μL	￥1980.00

下載說明 ①

Overview

Product name:	NUB1 rabbit pAb
Reactivity:	Human;Mouse;Monkey
Alternative Names:	NUB1; NYREN18; NEDD8 ultimate buster 1; Negative regulator of ubiquitin-like proteins 1; Renal carcinoma antigen NY-REN-18
Source:	Rabbit
Dilutions:	Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Immunogen:	The antiserum was produced against synthesized peptide derived from human NYREN18. AA range:566-615
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Observed Band:	70kD
GeneID:	51667
Human Swiss-Prot No:	Q9Y5A7
Cellular localization:	Nucleus . Predominantly nuclear.
Background:	This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splici

Western Blot analysis of various cells using NUB1 Polyclonal Antibody diluted at 1:2000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003,Inventbiotech,MN,USA).
Immunohistochemistry analysis of paraffin-embedded human tonsil tissue, using NYREN18 Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from COS7 cells, using NYREN18 Antibody. The lane on the right is blocked with the synthesized peptide.

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