黄色网站看片欧美-成人大片男人的天堂-女人被免费看在线看-在线观看视频一区网-日日摸日日添日日透 情久久国产视频网站上,青青青国产在线视频在线观看,久久99中文字幕久久,亚洲不卡免费视频

產(chǎn)品中心

p14 rabbit pAb
一鍵復制產(chǎn)品信息
ES3095
規(guī)格： 價格：
50μL ￥1280.00
100μL ￥1980.00

Overview

Product name: p14 rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: CDKN2A; CDKN2; MLM; Cyclin-dependent kinase inhibitor 2A; isoform 4; p14ARF; p19ARF
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human p14 ARF. AA range:71-120
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 18kD
GeneID: 1029
Human Swiss-Prot No: Q8N726
Cellular localization: Nucleus, nucleolus . Nucleus, nucleoplasm .; [Isoform smARF]: Mitochondrion .
Background: CDKN2A generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by CDKN2A, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. CDKN2A is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
關閉

在線咨詢

Online consultation

  • 在線咨詢
  • 技術(shù)支持

關注微信公眾號

微信掃一掃立即咨詢

微信掃一掃立即咨詢

關閉